Core needle biopsy versus fine needle aspiration biopsy in breast—A historical perspective and opportunities in the modern era
Article first published online: 14 OCT 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 39, Issue 5, pages 380–388, May 2011
How to Cite
Nassar, A. (2011), Core needle biopsy versus fine needle aspiration biopsy in breast—A historical perspective and opportunities in the modern era. Diagn. Cytopathol., 39: 380–388. doi: 10.1002/dc.21433
- Issue published online: 12 APR 2011
- Article first published online: 14 OCT 2010
- Manuscript Accepted: 5 APR 2010
- Manuscript Received: 23 OCT 2009
- fine-needle aspiration biopsy;
- needle biopsy;
Breast fine-needle aspiration biopsy (FNAB) by palpation is on the decline, due to its limitations in diagnostic accuracy, decreased sensitivity, and its replacement with core needle biopsy (CNB). Despite its decreasing utility, superficial fine-needle aspiration (FNA) in breast is still the main modality for evaluating metastatic lesions, recurrence, and axillary lymph node metastasis. New modalities including proteomic pattern expression and methylation profiling of breast lesions are other promising techniques that can be used as ancillary tests for refining the diagnosis of breast lesions using FNAB. Image-guided breast FNA proves to be a successful alternative with high sensitivity and specificity. In this review, the advantages, disadvantages, and inherent limitations of breast FNA and CNB, and new advanced techniques are discussed. Diagn. Cytopathol. 2011. © 2010 Wiley-Liss, Inc.