Cytological findings of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation: A study of eight cases
Article first published online: 2 NOV 2010
Copyright © 2010 Wiley Periodicals, Inc.
Volume 40, Issue S1, pages E16–E20, May 2012
How to Cite
Hirokawa, M., Kuma, S., Miyauchi, A. (2012), Cytological findings of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation: A study of eight cases. Diagn. Cytopathol., 40: E16–E20. doi: 10.1002/dc.21511
- Issue published online: 22 MAY 2012
- Article first published online: 2 NOV 2010
- Manuscript Accepted: 3 JUL 2010
- Manuscript Received: 16 APR 2010
- mucoepidermoid carcinoma;
- intracytoplasmic lumina;
The purpose of this article is to describe the cytologic findings of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation (ITET/CASTLE) in detail and discuss its differential diagnoses. We examined cytologic specimens taken from eight ITET/CASTLE cases, who underwent fine needle aspiration. Cytologic features of ITET/CASTLE include (1) hypercellularity, (2) large cell clusters without papillary or follicular pattern, (3) round or spindle tumor cells with distinct nucleoli and cell border, (4) few keratinized cells and intracytoplasmic lumina (ICL), and (5) lymphocytic background. The differential diagnoses included poorly differentiated carcinoma, metastatic lymphoepithelioma, squamous cell carcinoma, and mucoepidermoid carcinoma. The presence of individual keratinizing cells and ICL and the location of the tumor may be helpful in indicating ITET/CASTLE. Diagn. Cytopathol. 2012;40:E16–E20. © 2010 Wiley Periodicals, Inc.