Cytomorphology of ALK+ anaplastic large cell lymphoma displaying spindle cells mimicking a sarcomatous tumor: Report of a case
Article first published online: 1 OCT 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 39, Issue 10, pages 775–779, October 2011
How to Cite
Vij, M., Dhir, B., Verma, R., Agrawal, V., Agarwal, V., Jaiswal, S. and Pandey, R. (2011), Cytomorphology of ALK+ anaplastic large cell lymphoma displaying spindle cells mimicking a sarcomatous tumor: Report of a case. Diagn. Cytopathol., 39: 775–779. doi: 10.1002/dc.21552
- Issue published online: 14 SEP 2011
- Article first published online: 1 OCT 2010
- Manuscript Accepted: 22 AUG 2010
- Manuscript Received: 22 JUN 2010
- anaplastic large cell lymphoma (ALCL);
- anaplastic lymphoma kinase (ALK);
- spindle cells
Anaplastic large cell lymphoma (ALCL) is a lymphoma of T-cell or null-cell lineage characterized by molecular abnormalities involving anaplastic lymphoma kinase (ALK) gene and expression of ALK protein and CD30. Cytologic diagnosis of this entity is often a challenge and diagnostic difficulties are encountered when cytomorphology deviates from the usual descriptions. The reports of FNAC diagnosis of ALCL are rather limited. Histology and immunohistochemistry are usually required to confirm the diagnosis. We discuss a case of ALCL suspected on cytology in which a differential diagnosis of soft tissue sarcoma was also considered because of the presence of spindle-shaped and strap cells. Histology and immunohistochemistry confirmed the diagnosis of ALK+ ALCL with tumor cells displaying strong immunoreactivity for leucocyte common antigen, CD3, ALK-1 and CD30. We emphasize that the cytological features which may help in distinguishing sarcomatoid ALCL from soft tissue sarcoma are the presence of “hallmark cells,” lymphoglandular bodies and admixed mature small lymphocytes. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc.