Adenosquamous carcinoma of the lung diagnosed by cytology?: A diagnostic dilemma
Article first published online: 17 MAR 2011
Copyright © 2011 Wiley Periodicals, Inc.
Volume 40, Issue 9, pages 830–833, September 2012
How to Cite
Shelton, D. A., Rana, D. N., Holbrook, M., Taylor, P. and Bailey, S. (2012), Adenosquamous carcinoma of the lung diagnosed by cytology?: A diagnostic dilemma. Diagn. Cytopathol., 40: 830–833. doi: 10.1002/dc.21664
- Issue published online: 13 AUG 2012
- Article first published online: 17 MAR 2011
- Manuscript Accepted: 12 JAN 2011
- Manuscript Received: 17 NOV 2010
- adenosquamous carcinoma;
- bronchial brush;
- pleural fluid;
- non-small-cell carcinoma
Adenosquamous cell carcinomas of the lung are rare tumours and are associated with a poor prognosis compared to other non-small cell carcinomas. We report a case of a solitary lung carcinoma evaluated by bronchial brush and lavage cytology, bronchial biopsy and pleural fluid cytology. Cytological assessment of the pleural fluid demonstrated non-small cell carcinoma and immunohistochemical staining confirmed a metastatic lung adenocarcinoma. The bronchial brush and lavage specimens, however, demonstrated the cytomorphological features of squamous cell carcinoma, which was confirmed by the bronchial biopsy.
The finding of a mixed squamous and glandular component predicts a poor prognosis for this patient. The identification of a squamous component with the non-small cell carcinoma is important as this excludes the patient from anti-VEGF monoclonal antibody treatment due to the increased risk of haemorrhage. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.