Fine-needle aspiration diagnosis of an intraosseous amyloidoma
Article first published online: 4 MAY 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Bone and Soft Tissue
Volume 40, Issue S2, pages E114–E117, August 2012
How to Cite
Factor, R. E., Layfield, L. J., Grossmann, A. H., Crim, J. R., Price, S. L. and Randall, R. (2012), Fine-needle aspiration diagnosis of an intraosseous amyloidoma. Diagn. Cytopathol., 40: E114–E117. doi: 10.1002/dc.21686
- Issue published online: 27 AUG 2012
- Article first published online: 4 MAY 2011
- Manuscript Accepted: 9 FEB 2011
- Manuscript Received: 20 JAN 2011
- plasma cell dyscrasia
Fine-needle aspiration (FNA) is frequently used as the initial diagnostic procedure for the investigation of bone and soft tissue masses. The majority of the lesions detected will represent metastatic carcinoma. Amyloid is a rare cause of a bone mass, with less than 15 published reports describing amyloid deposition within bone. The majority of reported cases involve the vertebral column. We report the finding of a massive amyloidoma of the iliac wing in a 46-year-old man. FNA smears and cell block preparations demonstrated fragments of waxy acellular material misinterpreted as necrotic debris. Subsequent open biopsy established the diagnosis of amyloid with congo red staining demonstrating apple green birefringence. Subsequent workup disclosed the patient to have anemia, hypogammaglobulinemia and trace monoclonal light chain gammopathy. Bone marrow examination revealed CD138a positive lambda restricted plasma cells consistent with plasma cell dyscrasia. Careful attention to the staining characteristics of amyloid in FNA derived material should allow the diagnosis of amyloidoma. 2012. © 2011 Wiley Periodicals, Inc.