Epithelioid angiosarcoma of the kidney: A diagnostic dilemma in fine-needle aspiration cytology
Article first published online: 22 JUN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Bone and Soft Tissue
Volume 40, Issue S2, pages E131–E139, August 2012
How to Cite
Singh, C., Xie, L., Schmechel, S. C., Manivel, J. C., Pambuccian, S. E. (2012), Epithelioid angiosarcoma of the kidney: A diagnostic dilemma in fine-needle aspiration cytology. Diagn. Cytopathol., 40: E131–E139. doi: 10.1002/dc.21762
- Issue published online: 27 AUG 2012
- Article first published online: 22 JUN 2011
- Manuscript Accepted: 21 MAY 2011
- Manuscript Received: 24 FEB 2011
- fine-needle aspiration
Epithelioid angiosarcomas (EAS) of kidney are rare and aggressive tumors with noncharacteristic imaging features that overlap with those of inflammatory conditions and renal cell carcinoma (RCC). We report the fine-needle aspiration (FNA) cytology findings of a case of EAS that involved the left kidney of an 83-year-old male. The smears and cell block sections showed pleomorphic epithelioid cells with ample cytoplasm, eccentric nuclei, occasional cytoplasmic hyaline globules, and rare intracytoplasmic lumina. Immunohistochemical stains performed on cellblock sections showed that the tumor cells were positive for vimentin, CD31, CD34, Factor VIII, and CD10, but showed no staining for cytokeratins AE1/AE3 and 8/18, HMB45, CD45, smooth muscle actin, and S100. The morphological and immunohistochemical distinction between EAS, primary tumors of the kidney, and other epithelioid and rhabdoid neoplasms is discussed. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.