Cytomorphologic diagnosis and HPV testing of metastatic and primary oropharyngeal squamous cell carcinomas: A review and summary of the literature
Article first published online: 20 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: Symposium Issue
Volume 40, Issue 6, pages 491–497, June 2012
How to Cite
Jarboe, E. A., Hunt, J. P., Layfield, L. J. (2012), Cytomorphologic diagnosis and HPV testing of metastatic and primary oropharyngeal squamous cell carcinomas: A review and summary of the literature. Diagn. Cytopathol., 40: 491–497. doi: 10.1002/dc.22837
- Issue published online: 22 MAY 2012
- Article first published online: 20 FEB 2012
- Manuscript Accepted: 13 DEC 2011
- Manuscript Received: 17 OCT 2011
- fine-needle aspiration;
A significant proportion of squamous cell carcinomas (SCC) of the oropharynx are associated with high-risk human papillomavirus (HPV). These HPV-related carcinomas are prognostically and therapeutically different from traditional SCC of the head and neck. Cervical metastases from head and neck primary SCC are frequently investigated by fine-needle aspiration (FNA). HPV testing of cytologic samples from these lesions would potentially simplify diagnosis and therapeutic planning. This review summarizes current methodologies for HPV testing of FNA specimens and the role of HPV typing in diagnosis, prediction of prognosis, and selection of therapy. Diagn. Cytopathol. 2012;40:491–497. © 2012 Wiley Periodicals, Inc.