Amyloidomas of soft parts: Diagnosis by fine-needle aspiration
Article first published online: 23 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: Bone and Soft Tissue
Volume 40, Issue S2, pages E126–E130, August 2012
How to Cite
Elkins, C. T., Scharschmidt, T. J. and Wakely, P. E. (2012), Amyloidomas of soft parts: Diagnosis by fine-needle aspiration. Diagn. Cytopathol., 40: E126–E130. doi: 10.1002/dc.22844
- Issue published online: 27 AUG 2012
- Article first published online: 23 FEB 2012
- Manuscript Accepted: 12 JAN 2012
- Manuscript Received: 19 OCT 2011
- Manuscript Revised: 10 JAN 2011
- fine needle aspiration;
A tumoral mass of amyloid (amyloidoma) arising in the soft tissues of the distal extremities is exceedingly unusual, and applying the fine-needle aspiration (FNA) biopsy technique to specifically diagnose this condition is even more infrequent. Herein, we report an example of two separate amyloidomas arising in the right calf of an otherwise asymptomatic elderly man who was referred to the sarcoma clinic because these masses clinically and radiographically simulated a malignant neoplasm. The fine-needle aspirate yielded amorphous, acellular, dense blue material on Romanowsky-stained smears and smudgy acellular cyanophilic material on Papanicolaou-stained smears. The aspirate procured cell-block contained hyalinized eosinophilic acellular material on H&E stain that was Congo-red positive and displayed yellow-green birefringence with polarization. Unlike prior assertions to the contrary, a diagnosis of amyloidoma is possible using FNA cytopathology even in patients without a known underlying amyloidogenic disorder. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.