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Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: A histochemical, immunohistochemical, and molecular report

  1. Claudio Bellevicine M.D.1,
  2. Umberto Malapelle B.S.1,
  3. Antonino Iaccarino Ph.D.1,
  4. Pietro Schettino M.D.2,
  5. Vincenzo Napolitano M.D.2,
  6. Pio Zeppa M.D., Ph.D.3,
  7. Giancarlo Troncone M.D., Ph.D.1,*

Article first published online: 25 SEP 2012

DOI: 10.1002/dc.22923

Issue

Diagnostic Cytopathology

Diagnostic Cytopathology

Volume 41, Issue 1, pages 77–80, January 2013

Additional Information

How to Cite

Bellevicine, C., Malapelle, U., Iaccarino, A., Schettino, P., Napolitano, V., Zeppa, P. and Troncone, G. (2013), Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: A histochemical, immunohistochemical, and molecular report. Diagn. Cytopathol., 41: 77–80. doi: 10.1002/dc.22923

Author Information

  1. 1

    Department of Biomorfologic and Functional Sciences, University of Naples Federico II, Naples, Italy

  2. 2

    Endoscopic Surgery, Second University of Naples, Naples, Italy

  3. 3

    San Giovanni di Dio e Ruggi d'Aragona, University of Salerno, Salerno, Italy

*Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli Studi di Napoli Federico II, via Sergio Pansini 5, 80131, Napoli, Italia

Publication History

  1. Issue published online: 17 DEC 2012
  2. Article first published online: 25 SEP 2012
  3. Manuscript Accepted: 9 AUG 2012
  4. Manuscript Revised: 15 JUN 2012
  5. Manuscript Received: 27 FEB 2012

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Keywords:

  • pancreatic adenocarcinoma;
  • EUS-FNA;
  • foamy gland pattern;
  • special stains;
  • molecular cytopathology

Abstract

The foamy gland pattern (FGP) may impart to pancreatic ductal adenocarcinoma (PDA) a deceptively benign appearance. Thus, its diagnosis on FNA is challenging. A case of PDA with FGP, that was suspected on Diff Quik smears, diagnosed on cell-block preparation and confirmed by ancillary stains and molecular techniques, is here reported. The diagnostic interpretation of foamy atypical cells on direct smears may benefit from cell block preparation and from ancillary techniques. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc.

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