The cells of benign and malignant hemangiopericytomas in aspiration biopsy

Authors

  • Gia-Khanh Nguyen MD,

    Corresponding author
    1. Division of Anatomical Pathology, Department of Laboratory Medicine, the University of Alberta Hospitals, Edmonton, Alberta, Canada
    • Division of Anatomical Pathology, University of Alberta Hospitals 8440 112 St., Edmonton, Alberta, Canada T6G 2B7
    Search for more papers by this author
  • Roy Neifer B.Sc., A.R.T., C.T. (I.A.C.)

    1. Division of Anatomical Pathology, Department of Laboratory Medicine, the University of Alberta Hospitals, Edmonton, Alberta, Canada
    Search for more papers by this author

Abstract

Samples obtained by fine-needle biopsy of two benign and one malignant hemangiopericytoma revealed tumor cells with round, oval, or spindle-shaped nuclei, with variable and ill-defined filmy cytoplasm. The nuclei had a finely granular chromatin pattern with or without inconspicuous nucleoli. They were seen singly or in loose or dense cellular clusters. Focal gland-like arrangement of tumor cells was noted in some cellular clusters. Benign endothelial cells were seen among tumor cells and were not cohesive to the latter. The benign and malignant nature of hemangiopericytoma cannot be predicted by examination of the cells present in the aspirates. Also, a specific diagnosis of hemangiopericytoma could not be made on cytologic basis alone as cells of hemangiopericytoma were difficult to differentiate from those of other spindle-cell mesenchymal tumors.

Ancillary