Aspiration cytology of chromophobe cell carcinoma of the kidney

Authors

  • Dr. Mohammed Akhtar M.D., F.C.A.P.,

    Corresponding author
    1. Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    • Department of Pathology and Laboratory Medicine (MBC 10), King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
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  • M. Ashraf Ali M.D., F.R.C.P.C., F.C.A.P.

    1. Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Abstract

Fine-needle aspiration biopsy findings in three cases of chromophobe cell carcinoma are described and correlated with histologic and ultrastructural observations. In addition, comparisons are made with three cases each of oncocytoma and granular cell carcinoma. The cells in aspiration smears from chromophobe cell carcinoma closely correlated with histologic pattern of three cell types which were not present in oncocytomas and granular cell carcinomas. These cells had prominent cell borders, and their cytoplasm was either opaque and granular (type I) or variably translucent and reticular (type II and III). Ultrastructurally, the translucent areas within the cytoplasm contained large numbers of microvesicles which were unique to chromophobe cell carcinoma and were not seen in other neoplasms. Fine-needle aspiration may be used to diagnose chromophobe cell carcinoma and distinguish it from other related renal neoplasms. © 1995 Wiley-Liss, Inc.

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