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Vitamin B12, folate, and Alzheimer's disease
Article first published online: 30 AUG 2002
DOI: 10.1002/ddr.10066
Copyright © 2002 Wiley-Liss, Inc.
Issue
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Drug Development Research
Special Issue: New Drug Development for Alzheimer's Disease—Part 1
Volume 56, Issue 2, pages 111–122, June 2002
Additional Information
How to Cite
Wang, H.-X. (2002), Vitamin B12, folate, and Alzheimer's disease. Drug Dev. Res., 56: 111–122. doi: 10.1002/ddr.10066
Publication History
- Issue published online: 30 AUG 2002
- Article first published online: 30 AUG 2002
Funded by
- Karolinska Institute; Alzeimerfonden; Gamla Tjänarinnor Foundation
REFERENCES
- , . 1979. Nutritional anemia: its understanding and control with special reference to the work of the World Health Organization. Am J Clin Nutr 32:368–417.
- , , . 1994. Cobalamin levels are not reduced in Alzheimer's disease: results from a population-based study. J Am Geriatr Soc 42:132–136.
- , , , , , , . 1990. Vitamin B12 and folate status in acute geropsychiatric in patients: affective and cognitive characteristics of a vitamin nondeficient population. Biol Psychiatry 27:125–137.
- , , . 1998. The effect of vitamin B12 deficiency on older veterans and its relationship to health. J Am Geriatr Soc 46:1199–1206.
- , , , , . 1997. Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: the Rotterdam Study. J Intern Med 242:339–347.
- . 1996. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev 54:382–390.Direct Link:
- , , , . 1995. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274:1049–1057.
- , , . 1989. Dietary intake and clinical, anthropometric and biochemical indices of malnutrition in elderly demented patients and non-demented subjects. Psychol Med 19:383–391.
- , , , , , , , , , . 1995. The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol 1995; 54:245–253.Direct Link:
- . 2001. Prevention of vitamin B12 deficiency in old age. Am J Clin Nutr 73:151–152.
- , , , , , . 1998. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55:1449–1455.
- , . 1984. Low serum vitamin B12 in Alzheimer-type dementia. Age Ageing 13:101–105.
- , . 1978. Evidence that some patients with pernicious anemia are not recognized by rediadilution assay for cobalamin in serum. N Engl J Med 299:816–818.
- , , , , , . 1994. Serum vitamin levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study. J Am Geriatr Soc 42:933–936.
- , , , , . 1995. Vitamin B12 deficiency and dementia. Int Psychogeriatr 7:85–88.
- , . 1966. The serum vitamin B-12 in the elderly. Gerontol Clin (Basel) 8:220–225.
- . 2000. Homocysteine and neurological disease. Arch Neurol 57:1422–1427.
- , . 1959. Vitamin B12 levels in senile dementia and confusional states. Geriatrics 14:367–373.
- , , . 2000. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function. Int J Geriatr Psychiatry 15:226–233.Direct Link:
- , , , . 1998. Folate status, vascular disease and cognition in elderly Canadians. Age Ageing 27:485–491.
- , , , , , , . 1997. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr 26:1–13.
- , . 2002. Epidemiology of dementia. In: Oxford Elsevier Science, Ltd. BollerF, GrafmanJ, editors. Handbook of Neuropsychology. Oxford: Elsevier Science, Ltd.
- , , . 1983. Association between nutritional status and cognitive functioning in a healthy elderly population. JAMA 249:2917–2921.
- , , , . 1999. Further evidence for the effects of vitamin B12 and folate status on episodic memory functioning: a population-based study of very old adults. Biol Psychiatry 45:1472–1480.
- , , , , , , , , . 1997. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 345:151–154.
- . 1997. Folate and cobalamin in psychiatric illness. Compr Psychiat 6:305–314.
- , , , , . 1990. Vitamin B12 levels in serum andd cerebrospinal fluid of people with Alzheimer's disease. Acta Psychiatr Scand 82:327–329.Direct Link:
- , , , , , , . 1997. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 52:M76–79.
- , , , . 1993. Prevalence of folate deficiency. Are age-related behavioral disorders improved by folate administration? Exp Aging Res 19:367–376.
- , , , , , . 1999. Total homocysteine and cognitive decline in a community-based sample of elderly subjects. Am J Epidemiol 150:283–289.
- , . 1987. Low serum cobalamin levels in primary degenerative dementia. Do some patients harbor atypical cobalamin deficiency states?. Arch Intern Med 147:429–431.
- , , , , , . 1998. Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. Int J Geriatr Psychiatry 13:611–616.Direct Link:
- , , , , , . 1997. Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment. Am J Clin Nutr 65:20–29.
- , . 1992. Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease. Acta Psychiatr Scand 86:301–305.Direct Link:
- , , , , . 1993. Carotid artery intimal-medial wall thickening and plasma homocysteine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation 87:1107–1113.
- , , , . 1992. Time dependency of cognitive recovery with cobalamin replacement: report of a pilot study. J Am Geriatr Soc 40:168–172.
- , . 1994. Familial Alzheimer's disease and vitamin B12 deficiency. Age Ageing 23:334–337.
- , , , , . 1998. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 13:235–239.Direct Link:
- , , . 2000. Subnormal serum vitamin B12 and behavioural and psychological symptoms in Alzheimer's disease. Int J Geriatr Psychiatry 15:415–418.Direct Link:
- , , , , . 1990. Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia. J Neurol Neurosurg Psychiatry 53:951–954.
- , , , , . 2000. Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements. Aging 12:199–207.
- , , . 2001. Improvement of cognitive function after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry 16:609–614.Direct Link:
- , , , , , . 1995. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346:1395–1398.
- , , , . 1993. Effect of advanced brain atrophy and vitamin deficiency on cognitive functions in non-demented subjects. Acta Neurol Scand 87:161–166.Direct Link:
- , , . 1988. Blood folates deficiencies and cognitive functioning in aging. Trends Biomed Gerontol 1:315–323.
- , , , , . 1992. Vitamin B12 in CSF: reduced CSF/serum B12 ratio in demented men. Acta Neurol Scand 85:276–281.Direct Link:
- , , , , . 1999. The role of the polymorphic genes apolipoprotein E and methylene-tetrahydrofolate reductase in the development of dementia of the Alzheimer type. Dement Geriatr Cogn Disord 10:245–251.
- , , , . 1989. Nutritional status of free-living Alzheimer's patients. Am J Med Sci 298:20–27.
- , , , . 1996. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 63:306–314.
- , , , , . 1987. Nutritional status and dietary intake in institutionalized patients with Alzheimer's disease and multiinfarct dementia. J Am Geriatr Soc 35:31–38.
- , , , , . 1993. Vitamin status and intake as primary determinants of homocysteine in an elderly population. JAMA 270:2693–2698.
- , , , , , , , . 2002. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476–483.
- , , , , . 2000. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study. Am J Clin Nutr 71:993–998.
- , . 1988. RBC folic acid levels and cognitive performance in elderly patients: a preliminary report. Biol Psychiatry 24:352–354.
- , , , , , , , . 1992. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 268:877–881.
- , , , . 1996. Dementia and subnormal levels of vitamin B12: effects of replacement therapy on dementia. J Neurol 243:522–529.
- , , , , , . 1993. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 39:1764.
- , , , . 2000. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 72:324–332.
- , , , . 1996. Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: a population-based study. Psychol Aging 11:487–496.
- , , , , , . 2001. Low levels of vitamin B12 and folate and Alzheimer's disease incidence. Neurology 56:1188–1194.
- , , , , . 2000. Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen Project. Neurology 54:2103–2107.

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