Application of Steroid Hormone Metabolomics in Search of Biomarkers in Clinical Research


Correspondence to: Alicja Kotłowska, Department of Food Sciences, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.



Preclinical Research

Metabolomics is a discipline that concentrates on the global assessment of endogenous metabolites present in a biological system. Metabolic profiling has been applied to cells, tissues, and/or biofluids in order to evaluate disease progress, broaden the understanding of the disorder, and to select potential biomarkers. Steroid hormones play an important role in the regulation of routine functions in the human body, and their measurement in biological samples is essential for the diagnosis of various endocrine disorders. The present overview describes various strategies and analytical techniques applied in metabolomic studies, particularly with reference to the steroid metabolic profiling useful for the search of novel biomarkers.