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Keywords:

  • Mycobacterium tuberculosis;
  • antituberculosis agents;
  • 3-isoxazolecarboxylic acid alkyl esters

Abstract

Preclinical Research

A new series of 5-aryl and 5-arylethenylisoxazole carboxylate derivatives was synthesized and evaluated for in vitro activity against Mycobacterium tuberculosis H37Rv. Several compounds exhibited minimum inhibitory concentrations in the low micromolar range (2.3–11.4 μM). A variety of substituents introduced around the isoxazole ring allowed the delineation of preliminary SARs for this new series of compounds.