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Antileishmanial Activity of Natural Product-Like Naphthoquinones


  • Funding: Financial support provided by Biosciences Division of SRI International is gratefully acknowledged.

Correspondence to: Jeremiah P. Malerich, SRI International, Center for Infectious Disease and Biodefense Research, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.



Preclinical Research

The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated against Leishmania major. Compound (15), an analog of the natural product pinnatal, was more active than amphotericin B against L. major. When tested against L. (Viannia) braziliensis and L. infantum, compound 15 showed similar activity to amphotericin B.