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Antileishmanial Activity of Natural Product-Like Naphthoquinones

Authors


  • Funding: Financial support provided by Biosciences Division of SRI International is gratefully acknowledged.

Correspondence to: Jeremiah P. Malerich, SRI International, Center for Infectious Disease and Biodefense Research, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.

E-mail: jeremiah.malerich@sri.com

Abstract

Preclinical Research

The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated against Leishmania major. Compound (15), an analog of the natural product pinnatal, was more active than amphotericin B against L. major. When tested against L. (Viannia) braziliensis and L. infantum, compound 15 showed similar activity to amphotericin B.

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