The authors declare no conflict of interest.
Synthesis and Pharmacological Evaluation of 6-Arylpyridazinones as Potent Vasorelaxants
Article first published online: 25 MAR 2013
© 2013 Wiley Periodicals, Inc.
Drug Development Research
Volume 74, Issue 5, pages 296–305, August 2013
How to Cite
Bansal, R., Kumar, D., Sharma, D., Calle, C. and Carron, R. (2013), Synthesis and Pharmacological Evaluation of 6-Arylpyridazinones as Potent Vasorelaxants. Drug Dev. Res., 74: 296–305. doi: 10.1002/ddr.21079
- Issue published online: 12 JUL 2013
- Article first published online: 25 MAR 2013
- Manuscript Accepted: 20 FEB 2013
- Manuscript Received: 17 JAN 2013
- University Grant Commission and Council for Scientific and Industrial Research, India
As part of a research program to identify compounds with potent antihypertensive properties, a new series of dihydropyridazin-3(2H)-one analogs was synthesized and evaluated for vasodilator activity in rat thoracic aortic rings. Most of the newly synthesized compounds displayed good vasorelaxant activity as compared with SK&F-93741 and hydralazine, with the N2-unsubstituted 4-isobutyramidophenylpyridazinone derivative 5 being the most potent vasorelaxant, producing vasorelaxation greater than that of hydralazine and equipotent to SK&F-93741. A significant effect of the 6-phenyl substituents and substitution at N-2 position of pyridazinone nucleus on the vasodilatory activity was observed.