Will One Size of Anticoagulant Dosage Fit All?
Article first published online: 21 OCT 2013
© 2013 Wiley Periodicals, Inc.
Drug Development Research
Special Issue: Thrombosis Drugs and Diagnostics. Part I
Volume 74, Issue 7, pages 406–412, November 2013
How to Cite
Bloemen, S., De Laat, M., De Laat, B., Hemker, H. C. and Al Dieri, R. (2013), Will One Size of Anticoagulant Dosage Fit All?. Drug Dev. Res., 74: 406–412. doi: 10.1002/ddr.21097
- Issue published online: 21 OCT 2013
- Article first published online: 21 OCT 2013
- thrombin generation
|Enabling Technology, Genomics, Proteomics||Preclinical Research|
New, direct thrombin and factor Xa inhibitors have been developed to reduce the well-established drawbacks of currently available anticoagulants such as a protracted duration of action and high inter- and intra-individual variation of dose-effect. New anticoagulants are noninferior and no less effective for thromboprophylaxis than low-molecular-weight heparins or vitamin K antagonists. They are currently administered at fixed doses without control of their effect on the clotting system. Whether they need monitoring cannot be answered because relevant data are lacking and present means of monitoring are inadequate. The individual response to a standard dose of (any) anticoagulant—the modern direct inhibitors included—is highly variable (∼30%), and the clinical effect of all anticoagulants is not dose independent. Therefore a fixed dose that is optimal for the average patient is suboptimal for a fair percentage of patients that are low responders (risk of re-thrombosis) and dangerous for an equally high percentage of high responders (risk of bleeding). A better understanding of individual differences in the response, either low or high, to anticoagulants, irrespective of their mode of action, should be a primary objective for pharmacotherapy over the next decade.