These authors contributed equally to this work.
Synthesis and Antimetastatic Effects of E-Salignone Amide Derivatives
Article first published online: 15 NOV 2013
© 2013 Wiley Periodicals, Inc.
Drug Development Research
Volume 75, Issue 2, pages 76–87, March 2014
How to Cite
Wang, H.-L., Qin, N., Liu, J., Jin, M.-N., Zhang, X., Jin, M.-H., Kong, D., Jiang, S.-D. and Duan, H.-Q. (2014), Synthesis and Antimetastatic Effects of E-Salignone Amide Derivatives. Drug Dev. Res., 75: 76–87. doi: 10.1002/ddr.21157
- Issue published online: 15 APR 2014
- Article first published online: 15 NOV 2013
- Manuscript Accepted: 8 OCT 2013
- Manuscript Received: 29 AUG 2013
- National Natural Science Foundation of China (NSFC). Grant Number: 81072540
- Tianjin Research Program of Applied Basic and Cutting-edge Technologies. Grant Numbers: 11JCZDJC20900, 12JCZDJC25800
- amide derivatives;
- breast cancer cells
The preparation of novel E-salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E-salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical 1H NMR, 13C NMR, and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA-MB-231 cells by using a transwell assay. Comparing with the positive control, LY294002, compounds 19b, 19d, and 19e exhibited significant inhibitory effects on the EGF-induced invasion of MB-MDA-231 cells. Moreover, compound 19b also had antimigration effects in wound-healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.