Teratological effects of industrial solvents

Authors

  • Dr. Sikta Pradhan,

    1. Department of Pharmacology, Howard University College of Medicine, Washington, D.C.
    Current affiliation:
    1. U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Division of Bioequivalence (HFD-258), 5600 Fishers Lane, Rockville, MD 20857
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  • Tushar K. Ghosh,

    1. Department of Pharmacology, Howard University College of Medicine, Washington, D.C.
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  • Dr. Sachin N. Pradhan

    Corresponding author
    1. Department of Pharmacology, Howard University College of Medicine, Washington, D.C.
    • Professor of Pharmacology, Howard University College of Medicine, Washington, D.C. 20059
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Abstract

Increasing exposure of pregnant mothers to various industrial solvents due to voluntary abuse or involuntary exposure in the work place is raising the possibility of production of teratological effects in the offsprings. Ethanol, which can be broadly categorized as a solvent and which is also extensively abused, is well known for its teratological deragements in humans, termed as “fetal alcohol syndrome” as well as in animals. Benzene and its derivatives (xylene and toluene), alcohols, glycols and glycol ethers, and other solvents have also been reported to produce various types of teratogenic effects in animal (e.g., mice, rats, and rabbits) studies. In the case of toluene, some teratogenic anomalies have been reported in three children of mothers exposed to pure toluene vapor throughout the pregnancy.

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