Protective effects of zinc L-carnosine (Z-103) on reserpine-induced gastric ulceration in rats
Article first published online: 5 OCT 2004
Copyright © 1992 Wiley-Liss, Inc.
Drug Development Research
Volume 27, Issue 1, pages 61–65, 1992
How to Cite
Cho, C. H. (1992), Protective effects of zinc L-carnosine (Z-103) on reserpine-induced gastric ulceration in rats. Drug Dev. Res., 27: 61–65. doi: 10.1002/ddr.430270107
- Issue published online: 6 MAR 2008
- Article first published online: 5 OCT 2004
- Manuscript Accepted: 4 MAY 1992
- Manuscript Received: 25 APR 1992
- zinc L-carnosine;
- gastric ulcers;
- mast cells;
- reserpinized rats
The present study examined the gastric protective effects of zinc L-carnosine (Z-103) in reserpinized rats. We also studied whether this antiulcer effect is related to the preservation of mast cells degranulation in the glandular mucosa. Reserpine administration (5 mg/kg, intraperitoneally [i.p.]) produced severe hemorrhagic glandular ulcers which were accompained with a marked decrease in mucosal mast cell counts. The severity of ulcers and mast cell degranulation were reduced by Z-103 when given orally 30 min before and 6 hr after reserpinization. However, this protection was not observed when the drug was administered as a single dose 30 min beforehand. The present findings extended the antiulcer action of Z-103 from stress- and ethanol-induced gastric damage to those on reserpine-provoked gastric ulcers. It also indicates that the protective action on reserpine ulceration is likely to be due to the stabilization on mast cell membrane in the glandular mucosa. © 1992 Wiley-Liss, Inc.