Influence of prenatal psychosocial stress on cytokine production in adult women
Version of Record online: 5 AUG 2008
Copyright © 2008 Wiley Periodicals, Inc.
Volume 50, Issue 6, pages 579–587, September 2008
How to Cite
Entringer, S., Kumsta, R., Nelson, E. L., Hellhammer, D. H., Wadhwa, P. D. and Wüst, S. (2008), Influence of prenatal psychosocial stress on cytokine production in adult women. Dev. Psychobiol., 50: 579–587. doi: 10.1002/dev.20316
- Issue online: 5 AUG 2008
- Version of Record online: 5 AUG 2008
- Manuscript Accepted: 18 APR 2008
- Manuscript Received: 14 FEB 2008
- German Research Foundation. Grant Number: WU 324/3-(1-3)
- US PHS (NIH). Grant Numbers: HD-047609, HD-041696, HD-33506
- prenatal stress;
The aim of the present study was to determine the association between prenatal stress and immune function in human adults. Peripheral blood mononuclear cells (PBMCs) from 34 healthy young women whose mothers experienced major negative life events during their pregnancy (Prenatal Stress, PS group, mean age 25, SD ± 4.34 years), and from a female comparison group (n = 28, CG, mean age 24 ± 3.40 years), were stimulated with phytohemagglutinin (PHA), and subsequent cytokine production was measured. A bias for T-helper 2 (Th2) cytokine production due to an overproduction of IL-4 relative to IFN-γ after PHA stimulation was observed in PS subjects. In addition, IL-6 and IL-10 were also significantly elevated. To the best of our knowledge, this study is the first to suggest a direct association between prenatal stress exposure and alterations in immune parameters in adult women. © 2008 Wiley Periodicals, Inc. Dev Psychobiol 50: 579–587, 2008.