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Review
Amblyopia: Background to the special issue on stroke recovery
Article first published online: 13 MAR 2012
DOI: 10.1002/dev.21022
Copyright © 2012 Wiley Periodicals, Inc.
Issue
Developmental Psychobiology
Special Issue: Recent Advances in Stroke Recovery: Implications for Understanding Developmental Changes in Brain Plasticity and Possible Treatments for Amblyopia
Volume 54, Issue 3, pages 224–238, April 2012
Additional Information
How to Cite
Maurer, D. and Hensch, T. K. (2012), Amblyopia: Background to the special issue on stroke recovery. Dev. Psychobiol., 54: 224–238. doi: 10.1002/dev.21022
Publication History
- Issue published online: 13 MAR 2012
- Article first published online: 13 MAR 2012
- Manuscript Accepted: 14 FEB 2012
- Manuscript Received: 13 FEB 2012
Funded by
- James S. McDonnell grant
- Abstract
- Article
- References
- Cited By
Keywords:
- amblyopia;
- deprivation;
- recovery;
- sensitive period;
- plasticity
Abstract
In this introductory article, we summarize the evidence from humans and animal models on the shaping of postnatal visual development by focused binocular input. When balanced input is missing during a sensitive period, deficits emerge, including seemingly permanent impairments in visual acuity that are labeled amblyopia. Rodent models have identified neurochemical changes that control the onset of such sensitive periods and molecular and structural brakes that lead to the diminution of the plasticity thereafter. Both animal and human studies of amblyopia have recently identified exciting ways to remediate vision in adulthood that bear some similarity to the interventions that have proved successful in promoting recovery from stroke. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 54:224-238, 2012.