Amblyopia: Background to the special issue on stroke recovery
Version of Record online: 13 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: Recent Advances in Stroke Recovery: Implications for Understanding Developmental Changes in Brain Plasticity and Possible Treatments for Amblyopia
Volume 54, Issue 3, pages 224–238, April 2012
How to Cite
Maurer, D. and Hensch, T. K. (2012), Amblyopia: Background to the special issue on stroke recovery. Dev. Psychobiol., 54: 224–238. doi: 10.1002/dev.21022
- Issue online: 13 MAR 2012
- Version of Record online: 13 MAR 2012
- Manuscript Accepted: 14 FEB 2012
- Manuscript Received: 13 FEB 2012
- James S. McDonnell grant
- sensitive period;
In this introductory article, we summarize the evidence from humans and animal models on the shaping of postnatal visual development by focused binocular input. When balanced input is missing during a sensitive period, deficits emerge, including seemingly permanent impairments in visual acuity that are labeled amblyopia. Rodent models have identified neurochemical changes that control the onset of such sensitive periods and molecular and structural brakes that lead to the diminution of the plasticity thereafter. Both animal and human studies of amblyopia have recently identified exciting ways to remediate vision in adulthood that bear some similarity to the interventions that have proved successful in promoting recovery from stroke. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 54:224-238, 2012.