Pauline Pan, Daniel H.S. Jin, and Munmun Chatterjee-Chakraborty contributed equally to organization, analyses, and/or writing.
The effects of vitamin D3 during pregnancy and lactation on offspring physiology and behavior in Sprague–Dawley rats
Version of Record online: 5 NOV 2012
© 2012 Wiley Periodicals, Inc.
Volume 56, Issue 1, pages 12–22, January 2014
How to Cite
Pan, P., Jin, D. H.S., Chatterjee-Chakraborty, M., Halievski, K., Lawson, D., Remedios, D., Smetka, C., Pinto, V., Parra, E. and Fleming, A. S. (2014), The effects of vitamin D3 during pregnancy and lactation on offspring physiology and behavior in Sprague–Dawley rats. Dev. Psychobiol., 56: 12–22. doi: 10.1002/dev.21086
- Issue online: 6 DEC 2013
- Version of Record online: 5 NOV 2012
- Manuscript Accepted: 26 SEP 2012
- Manuscript Received: 19 MAR 2012
- NSERC to A.S. Fleming
- Research Opportunity Program in Psychology at the University of Toronto at Mississauga
- vitamin D;
- behavior, biochemistry;
Recent findings show that developmental vitamin D deficiency leads to altered brain morphology and behavioral development in the rat offspring. We examined the effects of different dietary vitamin D levels in rat dams on behavior and biochemistry of the offspring. Females were divided into five conditions and received diets containing 0, 1,5, 3.3, 6.0, or 10.0 IU/g of vitamin D3 from mating to weaning. Offspring were tested as juveniles and as adults for anxiety, social learning and behavior, and locomotion. Results show that both deficient and excessive levels of vitamin D3 in juveniles lead to altered physiology and behavior. In juveniles but not adults, variations in vitamin D were related to variations in measures of anxiety and marginally, activity levels. For social behaviors, both juveniles and adults were affected by mothers' diets. In general, offspring of animals receiving abnormal concentrations of vitamin D showed the most deficits. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 56: 12–22, 2014.