The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Version of Record online: 4 MAY 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
Volume 26, Issue 4, pages 280–286, May 2010
How to Cite
Abdul-Ghani, M. A., Lyssenko, V., Tuomi, T., DeFronzo, R. A. and Groop, L. (2010), The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes. Diabetes Metab. Res. Rev., 26: 280–286. doi: 10.1002/dmrr.1084
- Issue online: 20 MAY 2010
- Version of Record online: 4 MAY 2010
- Manuscript Accepted: 4 APR 2010
- Manuscript Revised: 30 MAR 2010
- Manuscript Received: 24 NOV 2009
- Sigrid Juselius Foundation
- Folkhälsan Research Foundation
- Finnish Diabetes Research Foundation
- Swedish Research Council
- shape of glucose tolerance curve;
- prediction of diabetes;
The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM.
2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7–8 years of follow-up.
NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during OGTT had greater insulin sensitivity, better beta cell function and lower risk for future T2DM.
These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright © 2010 John Wiley & Sons, Ltd.