SEARCH

SEARCH BY CITATION

Keywords:

  • shape of glucose tolerance curve;
  • prediction of diabetes;
  • OGTT

Abstract

Background

The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM.

Methods

2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7–8 years of follow-up.

Results

NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during OGTT had greater insulin sensitivity, better beta cell function and lower risk for future T2DM.

Conclusions

These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright © 2010 John Wiley & Sons, Ltd.