Research Article

Evolution and predictors of morphological and functional arterial changes in the course of type 1 diabetes mellitus

  1. Ildikó Vastagh1,*,
  2. Tamás Horváth2,
  3. Géza Nagy3,
  4. Tímea Varga3,
  5. Eszter Juhász3,
  6. Viktória Juhász3,
  7. Márk Kollai2,
  8. Dániel Bereczki1,
  9. Anikó Somogyi3

Article first published online: 4 OCT 2010

DOI: 10.1002/dmrr.1133

Issue

Diabetes/Metabolism Research and Reviews

Diabetes/Metabolism Research and Reviews

Volume 26, Issue 8, pages 646–655, November 2010

Additional Information

How to Cite

Vastagh, I., Horváth, T., Nagy, G., Varga, T., Juhász, E., Juhász, V., Kollai, M., Bereczki, D. and Somogyi, A. (2010), Evolution and predictors of morphological and functional arterial changes in the course of type 1 diabetes mellitus. Diabetes Metab. Res. Rev., 26: 646–655. doi: 10.1002/dmrr.1133

Author Information

  1. 1

    Department of Neurology, Semmelweis University Faculty of Medicine, Budapest, Hungary

  2. 2

    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary

  3. 3

    2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

*Department of Neurology, Semmelweis University Faculty of Medicine, Balassa u. 6, Budapest H-1083, Hungary.

Publication History

  1. Issue published online: 28 OCT 2010
  2. Article first published online: 4 OCT 2010
  3. Manuscript Accepted: 7 SEP 2010
  4. Manuscript Revised: 3 SEP 2010
  5. Manuscript Received: 12 DEC 2009

Funded by

  • Ministry of Health
  • Republic of Hungary

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Keywords:

  • duration of type 1 diabetes mellitus;
  • common carotid artery;
  • intima-media cross-section area;
  • intima-media thickness;
  • pulse wave velocity;
  • stiffness index

Abstract

Background

Diabetes mellitus results in accelerated atherosclerosis. We evaluated preclinical, morphological and functional vascular changes in type 1 diabetes mellitus.

Methods

Diameter, intima-media thickness, intima-media cross-section area, and elasticity features (compliance, distensibility coefficient, circumferential strain, stiffness index, incremental elastic modulus) of the common carotid arteries and carotid-femoral pulse wave velocity were studied in 42 patients with type 1 diabetes mellitus without macroangiopathy, and 41 control subjects matched for sex, age and body mass index using an ultrasonographic vessel wall-movement tracking system and applanation tonometry.

Results

Significantly larger intima-media thickness (523 ± 55 versus 567 ± 89 µm, p < 0.01), intima-media cross-section area (11.60 ± 1.81 versus 13.08 ± 3.02 mm2, p < 0.01), SI (5.58 ± 1.24 versus 7.08 ± 2.69, p < 0.01) and pulse wave velocity (6.00 ± 0.82 versus 6.61 ± 1.56 m/s, p < 0.05) were found in type 1 diabetes mellitus patients compared to controls. When type 1 diabetes mellitus patients with short and long disease duration (≤ or > 10 years) were compared, diameter (6450 ± 433 versus 6847 ± 750 µm, p < 0.05), intima-media cross-section area (11.97 ± 1.98 versus 14.01 ± 3.43 mm, p < 0.05) and pulse wave velocity (5.90 ± 0.92 versus 7.20 ± 1.74 m/s, p < 0.01) differed significantly. When multivariate analyses were restricted to type 1 diabetes mellitus patients, age was an independent predictor of stiffness index and pulse wave velocity, the duration of diabetes mellitus of intima-media cross-section area and pulse wave velocity, systolic blood pressure of diameter and pulse wave velocity, and low-density lipoprotein-cholesterol of intima-media thickness, intima-media cross-section area and stiffness index.

Conclusions

There are differences in the time course of evolution and in predictors of morphological and functional changes in arteries in type 1 diabetes mellitus. Copyright © 2010 John Wiley & Sons, Ltd.

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