The changing epidemiology of type 1 diabetes: why is it going through the roof?
Article first published online: 29 OCT 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
Volume 27, Issue 1, pages 3–13, January 2011
How to Cite
Vehik, K. and Dabelea, D. (2011), The changing epidemiology of type 1 diabetes: why is it going through the roof?. Diabetes Metab. Res. Rev., 27: 3–13. doi: 10.1002/dmrr.1141
- Issue published online: 10 JAN 2011
- Article first published online: 29 OCT 2010
- Manuscript Accepted: 29 SEP 2010
- Manuscript Revised: 12 JUL 2010
- Manuscript Received: 30 APR 2010
- type 1 diabetes;
The incidence of type 1 diabetes is increasing and this may double the burden of disease in our youngest by 2020. The recent increase in incidence is mostly happening in the very young and those with moderate genetic susceptibility. Many environmental factors have been implicated, but no major determinants have been clearly identified, and the mechanisms of involvement remain elusive. This review summarizes current research efforts directed at understanding the possible reasons for this increase, including the role of viruses, gut microbiota, early life feeding patterns, perinatal factors and childhood growth patterns. It also provides a road map for future research directions. Copyright © 2010 John Wiley & Sons, Ltd.