Decreased variation of inflammatory markers in gestational diabetes
Article first published online: 2 MAR 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
Volume 27, Issue 3, pages 269–276, March 2011
How to Cite
Pöyhönen-Alho, M., Ebeling, P., Saarinen, A. and Kaaja, R. (2011), Decreased variation of inflammatory markers in gestational diabetes. Diabetes Metab. Res. Rev., 27: 269–276. doi: 10.1002/dmrr.1170
- Issue published online: 2 MAR 2011
- Article first published online: 2 MAR 2011
- Accepted manuscript online: 4 JAN 2011 04:42AM EST
- Manuscript Accepted: 21 DEC 2010
- Manuscript Revised: 20 DEC 2010
- Manuscript Received: 1 OCT 2010
- Heart Research Foundation
- Aarne Koskelo Foundation
- Maire Taponen Foundation
- Finnish Medical Funding
- Jorvi Hospital Research Funding
- Biomedicum Foundation and Special Government Funding of Finland. Grant Number: T1030A0087
- gestational diabetes;
- amyloid A;
Gestational diabetes is a prediabetic state. Sub-clinical inflammation may play a role in the transition from gestational diabetes to type 2 diabetes; the role of the autonomic nervous system as a mediating system has been raised. We aimed to study the association of the sympathetic nervous system and sub-clinical inflammation in women with gestational diabetes.
We studied 41 Caucasian women with gestational diabetes and 22 healthy pregnant and 14 non-pregnant controls. We assayed plasma noradrenaline, insulin, C-reactive protein, interleukin-6, insulin growth factor-1, serum amyloid A, steroid hormone-binding globulin, α-1 acid glycoprotein and cortisol at 2400, 0400 and 0700 h.
No differences existed in the concentrations of inflammatory markers between gestational diabetes and normal pregnancy but women with gestational diabetes showed loss of variation in C-reactive protein and serum amyloid A. Levels of hormone-binding globulin were lower in hypertensive compared with normotensive women with gestational diabetes at all time points and lowest at midnight when α-1 acid glycoprotein levels were higher in hypertensive women.
Gestational diabetes is associated with loss of natural variation of C-reactive protein and serum amyloid A, suggesting altered modulation of inflammation. Hypertension in gestational diabetes seems not to be associated with higher levels of inflammatory markers other than α-1 acid glycoprotein. Copyright © 2011 John Wiley & Sons, Ltd.