See Appendix for the complete list of investigators.
Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin
Article first published online: 5 FEB 2013
Copyright © 2012 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
Volume 29, Issue 2, pages 166–170, February 2013
How to Cite
Pham, M. N., Kolb, H., Mandrup-Poulsen, T., Battelino, T., Ludvigsson, J., Pozzilli, P., Roden, M., Schloot, N. C. and European C-Peptide Trial (2013), Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin. Diabetes Metab. Res. Rev., 29: 166–170. doi: 10.1002/dmrr.2378
- Issue published online: 5 FEB 2013
- Article first published online: 5 FEB 2013
- Accepted manuscript online: 30 NOV 2012 12:03AM EST
- Manuscript Accepted: 26 NOV 2012
- Manuscript Revised: 12 NOV 2012
- Manuscript Received: 24 JUL 2012
- type 1 diabetes
We investigated the adipokines adiponectin, leptin and resistin as serum biomarkers of beta-cell function in patients with type 1 diabetes.
One hundred and eighteen patients with type 1 diabetes (20.3 ± 7.5 years) diagnosed <5 years underwent standardized mixed meal test (MMTT) for 2 h. Systemic concentrations of C-peptide, adiponectin, leptin and resistin obtained during MMTT were measured and compared between patient groups by multiple regression analysis.
Patients were divided by their adipokine levels in subgroups above or below the median level (‘high versus low’). High adiponectin levels (>10.6 µg/mL) were associated with lower C-peptide compared to the low adiponectin subgroup (p < 0.03). Increased leptin or resistin concentrations associated positively with beta-cell function even after adjustment for metabolic confounders (p < 0.04). The described associations between adipokines and C-peptide concentrations persisted in Spearman correlation tests (p < 0.05). Serum adipokines fell during MMTT (p < 0.05).
Serum adipokine levels differentially correlate with beta-cell function in type 1 diabetes independent of BMI or metabolic control. Serum adipokines should be investigated as biomarkers of beta-cell function in prospective studies and intervention trials in type 1 diabetes. Copyright © 2012 John Wiley & Sons, Ltd.