This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/dmrr.2381
Can we prevent beta cell apoptosis in type 2 diabetes?†
Copyright © 2012 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
- Accepted manuscript online: 5 DEC 2012 07:57AM EST
- Manuscript Accepted: 3 NOV 2012
- Manuscript Revised: 29 OCT 2012
- Manuscript Received: 4 SEP 2012
- Cited By
- beta cell;
- type 2 diabetes;
- beta cell regeneration
Since the publication of the United Kingdom Prospective Diabetes Study (UKPDS), the progressive nature of type 2 (DM2) diabetes has been identified as the main cause of failure to maintain a long term glycemic control. The need to adjust treatment as the disease progressed was recognized and algorithms for treatments in line with this concept were developed.
The UKPDS showed that the progressive character of the disease results from a steady reduction, of approximately 5% per year, in the ability of beta cells to secrete insulin, a process estimated to begin 10 to 12 years before diagnosis, which triggers the onset of diabetes when approximately 50% of beta cell function has been lost.  Copyright © 2012 John Wiley & Sons, Ltd.