• Open Access

The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children

Authors

  • Rosellina Margherita Mancina,

    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
    2. Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Italy
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    • These authors contributed equally to this work
  • Maria Antonella Burza,

    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
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    • These authors contributed equally to this work
  • Cristina Maglio,

    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
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  • Carlo Pirazzi,

    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
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  • Federica Sentinelli,

    1. Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy
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  • Michela Incani,

    1. Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy
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  • Tiziana Montalcini,

    1. Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Italy
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  • Arturo Pujia,

    1. Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Italy
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  • Tiziana Congiu,

    1. Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy
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  • Sandro Loche,

    1. Pediatric Endocrine Unit, Regional Hospital for Microcitaemia, Cagliari, Italy
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  • Sabrina Pilia,

    1. Pediatric Endocrine Unit, Regional Hospital for Microcitaemia, Cagliari, Italy
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  • Olov Wiklund,

    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
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  • Jan Borén,

    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
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  • Stefano Romeo,

    Corresponding author
    1. Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sweden
    • Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Italy
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  • Marco Giorgio Baroni

    Corresponding author
    1. Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy
    2. Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Italy
    • Pediatric Endocrine Unit, Regional Hospital for Microcitaemia, Cagliari, Italy
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Correspondence to: Stefano Romeo, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg Bruna Stråket 16 SE-413 45 Göteborg, Sweden.E-mail: stefano.romeo@wlab.gu.se

Marco Giorgio Baroni, Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Policlinico Universitario, 09042 Cagliari, Italy.E-mail: marcobaroni@medicina.unica.it

Abstract

Background

Childhood obesity is a growing epidemic worldwide, and it is associated with metabolic complications, such as insulin resistance. Recently, a genetic variation (rs7607980) in the COBLL1 gene has been associated with lower insulin resistance in adults. The aim of the study was to investigate if the association between COBLL1 rs7607980 genetic variant and lower insulin resistance was present early in life.

Methods

This sequence variant was genotyped in 878 overweight and obese children (mean age: 10 years) from Sardinia, Italy, from the outpatient clinic of the Pediatric Endocrine Unit, at the Regional Hospital for Microcitaemia in Cagliari. Insulin resistance was assessed by measurement of fasting circulating insulin levels before and after an oral glucose tolerance test and by HOMA-IR.

Results

The COBLL1 rs7607980 C allele was associated with lower fasting insulin and HOMA-IR levels (p = 0.002 and p = 0.035, respectively) in overweight and obese children. Importantly, lower insulin levels were also observed 2 h after oral glucose tolerance test in C allele carriers (p = 0.009).

Conclusions

The present study shows for the first time, the association between COBLL1 rs7607980 C allele, lower serum insulin levels and lower insulin resistance in overweight and obese children. Copyright © 2013 John Wiley & Sons, Ltd.

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