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Research Article
Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study
Article first published online: 24 JUN 2005
DOI: 10.1002/dmrr.573
Copyright © 2005 John Wiley & Sons, Ltd.
1520-7560/asset/cover.gif?v=1&s=518ef24df4af0f53197d5b36e1afedd4421360a2 "Diabetes/Metabolism Research and Reviews")
Additional Information
How to Cite
Pearce, M. S., Unwin, N. C., Parker, L. and Alberti, K. G. M. M. (2006), Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study. Diabetes/Metabolism Research and Reviews, 22: 118–125. doi: 10.1002/dmrr.573
Publication History
- Issue published online: 22 FEB 2006
- Article first published online: 24 JUN 2005
- Manuscript Revised: 16 MAY 2005
- Manuscript Accepted: 16 MAY 2005
- Manuscript Received: 17 DEC 2004
Funded by
- Wellcome Trust
- Minnie Henderson Trust
- Sir John Knott Trust
- Special Trustees of the Newcastle Hospitals
- Abstract
- Article
- References
- Cited By
Keywords:
- Barker hypothesis;
- insulin resistance;
- insulin secretion;
- lifecourse
Abstract
Background
Suboptimal nutrition during fetal life and infancy is suggested to increase insulin resistance in adulthood. This study investigated the proportion of variance in insulin secretion and resistance accounted for by factors operating at different stages of life using a cohort of all 1142 births in the city of Newcastle, UK in May and June 1947.
Methods
Detailed information was collected prospectively during childhood, including birth weight, growth and socio-economic circumstances. At age 50, 412 study members attended for clinical examination. Fasting and 30-min plasma insulin and glucose levels were determined and HOMA-IR and insulin secretion derived.
Results
Birth weight was not a significant predictor of HOMA-IR after adjustment for percent body-fat and waist-hip ratio. Duration of breastfeeding was significantly negatively associated with HOMA-IR in men. For both genders, fetal life explained directly little variation in either HOMA-IR or insulin secretion (0.1–5.6%). Compared to early life, adult lifestyle and body composition directly explained larger proportions of the variances for insulin secretion and HOMA-IR for men (11 and 22% respectively) and women (5.9 and 34%).
Conclusions
Insulin secretion is largely unexplained by these data. For insulin resistance, the evidence suggests a limited impact of early life and a larger impact of adult factors. Copyright © 2005 John Wiley & Sons, Ltd.