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Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction
Article first published online: 2 FEB 2006
DOI: 10.1002/dmrr.613
Copyright © 2005 John Wiley & Sons, Ltd.
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How to Cite
Piconi, L., Quagliaro, L., Assaloni, R., Da Ros, R., Maier, A., Zuodar, G. and Ceriello, A. (2006), Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab. Res. Rev., 22: 198–203. doi: 10.1002/dmrr.613
Publication History
- Issue published online: 2 MAY 2006
- Article first published online: 2 FEB 2006
- Manuscript Accepted: 15 NOV 2005
- Manuscript Revised: 17 JUN 2005
- Manuscript Received: 1 DEC 2004
Funded by
- Novartis Pharma, Basel, Switzerland
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- 1, , , , Effects of Fluctuating Glucose Levels on Neuronal Cells In Vitro, Neurochemical Research, 2012,
- 2, , , , , , , , , Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate, Experimental Cell Research, 2012, 318, 4, 350
- 3, , , , , , Glucose: A vital toxin and potential utility of melatonin in protecting against the diabetic state, Molecular and Cellular Endocrinology, 2012, 349, 2, 128
- 4, , , , Human pericyteâendothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment, Acta Diabetologica, 2012,
- 5, , , , , , Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius saponin of stem and leaf, Chinese Journal of Integrative Medicine, 2012,
- 6, , , , , , , , , , , Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose, Life Sciences, 2012, 90, 3-4, 99
- 7, , , , , The relationship between oxidative stress and the levels of serum circulating adhesion molecules in patients with hyperglycemia crises, Journal of Diabetes and its Complications, 2012,
- 8, , , , , , , α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells, Development, Growth & Differentiation, 2012, 54, 4Direct Link:
- 9, , , , , , , Adiponectin protects endothelial cells from the damages induced by the intermittent high level of glucose, Endocrine, 2011, 40, 3, 386
- 10, , , , , , , , Comparison of fasting capillary glucose variability between insulin glargine and NPH, Diabetes Research and Clinical Practice, 2011, 91, 1, e4
- 11, , , , Glucose exposure pattern determines glucagon-like peptide 1 receptor expression and signaling through endoplasmic reticulum stress in rat insulinoma cells, Biochemical and Biophysical Research Communications, 2011, 414, 1, 220
- 12, , , , , , High Glycemic Variability Assessed by Continuous Glucose Monitoring After Surgical Treatment of Obesity by Gastric Bypass, Diabetes Technology & Therapeutics, 2011, 13, 6, 625
- 13, , , , Human Vascular Endothelial Cells: A Model System for Studying Vascular Inflammation in Diabetes and Atherosclerosis, Current Diabetes Reports, 2011, 11, 3, 193
- 14, , , , , , , , , , , , , Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function, Proceedings of the National Academy of Sciences, 2011, 108, 33, 13829
- 15, , , Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: A Role for Mitochondria and the Nuclear Factor-E2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 Defense Pathway, Antioxidants & Redox Signaling, 2011, 14, 3, 469
- 16, , , , , , MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression, Diabetes Research and Clinical Practice, 2011, 91, 1, 94
- 17, , MicroRNAs mediate metabolic stresses and angiogenesis, Cellular and Molecular Life Sciences, 2011, 69, 7, 1049
- 18, , ‘Glycaemic variability’: a new therapeutic challenge in diabetes and the critical care setting, Diabetic Medicine, 2010, 27, 8Direct Link:
- 19, , , , , , , , , , , , , Acute hyperglycemia and contrast-induced nephropathy in primary percutaneous coronary intervention, American Heart Journal, 2010, 160, 6, 1170
- 20, , , , , , , Effects of blood glucose fluctuation on skin biophysical properties, structure and antioxidant status in an animal model, Clinical and Experimental Dermatology, 2010, 35, 1Direct Link:
- 21, Hyperglycaemia and the vessel wall: the pathophysiological aspects on the atherosclerotic burden in patients with diabetes, European Journal of Cardiovascular Prevention & Rehabilitation, 2010, 17, S15
- 22, , , Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes, Diabetologia, 2010, 53, 8, 1783
- 23, , , , , , Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation, Endocrine, 2010, 37, 1, 201
- 24, , , , , , , , , The effect of NF-κB pathway on proliferation and apoptosis of human umbilical vein endothelial cells induced by intermittent high glucose, Molecular and Cellular Biochemistry, 2010, 347, 1-2, 127
- 25, , , , Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine, Diabetes/Metabolism Research and Reviews, 2009, 25, 6Direct Link:
- 26, , , , , Elevated Glucose Impairs the Endothelial Cell Response to Shear Stress, Cellular and Molecular Bioengineering, 2009, 2, 4, 533
- 27, , , , , , Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration, Diabetologia, 2009, 52, 5, 921
- 28, , , , , Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension, Cell and Tissue Research, 2009, 337, 1, 103
- 29, , , , , , , , New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm, Frontiers in Neuroendocrinology, 2009, 30, 2, 119
- 30, , , , , , , , , Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism, Diabetes Research and Clinical Practice, 2009, 83, 1, 94
- 31, , , , , , , , , , Rapid âglycaemic swingsâ induce nitrosative stress, activate poly(ADP-ribose) polymerase and impair endothelial function in a rat model of diabetes mellitus, Diabetologia, 2009, 52, 5, 952
- 32, , , , , , , , , , , Ablation of NF-κB expression by small interference RNA prevents the dysfunction of human umbilical vein endothelial cells induced by high glucose, Endocrine, 2008, 35, 1, 63
- 33, Cardiovascular Disease and Modifiable Cardiometabolic Risk Factors, Clinical Cornerstone, 2008, 9, 2, 24
- 34, , , , Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications, Acta Diabetologica, 2008, 45, 3, 131
- 35, , , , , , , Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients, Diabetes & Metabolism, 2008, 34, 2, 117
- 36, , , , Peroxynitrite-induced protein nitration contributes to liver mitochondrial damage in diabetic rats, Journal of Diabetes and its Complications, 2008, 22, 5, 357
- 37
- 38, Cardiovascular disease and modifiable cardiometabolic risk factors, Clinical Cornerstone, 2007, 8, 3, 11
- 39Current literature in diabetes, Diabetes/Metabolism Research and Reviews, 2007, 23, 1Direct Link:
- 40, , , , , , , Effect of ghrelin on human endothelial cells apoptosis induced by high glucose, Biochemical and Biophysical Research Communications, 2007, 362, 3, 677
- 41, , Experimental IUGR and later diabetes, Journal of Internal Medicine, 2007, 261, 5Direct Link:
- 42, , , , , , , , High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15INK4b pathway, Archives of Biochemistry and Biophysics, 2007, 465, 1, 164
- 43, , , , , , , , Identification of cultivation-independent markers of human endothelial cell senescence in vitro, Biogerontology, 2007, 8, 4, 383
- 44, , , , , , In vitro evidence of glucose-induced toxicity in GnRH secreting neurons: high glucose concentrations influence GnRH secretion, impair cell viability, and induce apoptosis in the GT1-1 neuronal cell line, Fertility and Sterility, 2007, 88, 4, 1143
- 45, , , , , , , , , , , , , Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial cells in high glucose, Journal of Molecular Medicine, 2007, 86, 2, 185
- 46, , , , , , Melatonin is more effective than taurine and 5-hydroxytryptophan against hyperglycemia-induced kidney-cortex tubules injury, Journal of Pineal Research, 2007, 42, 2Direct Link:
- 47, , , , Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low density lipoproteins, European Journal of Nutrition, 2007, 46, 8, 431
- 48, , , , Targeting Endothelial Cells with Heme Oxygenase-1 Gene Using VE-Cadherin Promoter Attenuates Hyperglycemia-Mediated Cell Injury and Apoptosis, Antioxidants & Redox Signaling, 2007, 9, 12, 2065
- 49, Microvascular Consequences of Obesity and Diabetes, Comprehensive Physiology,Direct Link:

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