Correlation between vitamin D3 deficiency and insulin resistance in pregnancy
Article first published online: 2 JUL 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
Volume 24, Issue 1, pages 27–32, January 2008
How to Cite
Maghbooli, Z., Hossein-nezhad, A., Karimi, F., Shafaei, A.-R. and Larijani, B. (2008), Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab. Res. Rev., 24: 27–32. doi: 10.1002/dmrr.737
- Issue published online: 11 DEC 2007
- Article first published online: 2 JUL 2007
- Manuscript Revised: 31 JAN 2007
- Manuscript Accepted: 31 JAN 2007
- Manuscript Received: 7 AUG 2006
- insulin sensitivity;
- insulin resistance;
- Vitamin D;
The serum level of 25-hydroxyvitamin D deficiency has long been suspected as a risk factor for glucose intolerance and perhaps 1,25-dihydroxyvitamin D has a role in the regulation of insulin secretion. This study investigates the relation between 25-hydroxyvitamin D concentrations and insulin resistance in pregnant women.
A cross-sectional study was conducted on 741 pregnant women referred to five educating hospital clinics. Universal screening was performed with a GCT-50 g, and those with plasma glucose levels ≥ 7.2 mmol/L were diagnosed as GDM if they had an impaired GTT-100 g based on Carpenter and Coustan criteria. The levels of insulin and C-peptide were measured during OGTT-100 g test. The homeostasis model assessment index (HOMA) equation was used as the insulin resistance index. The concentrations of 25-hydroxyvitamin D, and PTH were also measured.
Total prevalence of vitamin D deficiency (<25 nmol/L) was found in 70.6% of pregnant women. Prevalence of severe vitamin D deficiency (<12.5) in GDM patients was higher than in normoglycaemic pregnancies. The regression model revealed a strong correlation between the HOMA index and serum levels of vitamin D.
These results show that a positive correlation of 25(OH) vitamin D concentrations with insulin sensitivity and vitamin D deficiency could be a confirmative sign of insulin resistance. Copyright © 2007 John Wiley & Sons, Ltd.