Joint first authors.
C-peptide constricts pancreatic islet arterioles in diabetic, but not normoglycaemic mice
Article first published online: 21 DEC 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Diabetes/Metabolism Research and Reviews
Volume 24, Issue 2, pages 165–168, February 2008
How to Cite
Nordquist, L., Lai, E. Y., Sjöquist, M., Jansson, L. and Persson, A. E. G. (2008), C-peptide constricts pancreatic islet arterioles in diabetic, but not normoglycaemic mice. Diabetes Metab. Res. Rev., 24: 165–168. doi: 10.1002/dmrr.805
- Issue published online: 28 JAN 2008
- Article first published online: 21 DEC 2007
- Manuscript Accepted: 4 OCT 2007
- Manuscript Revised: 3 OCT 2007
- Manuscript Received: 1 AUG 2007
- Juvenile Diabetes Research Foundation
- Swedish Medical Research Council. Grant Number: K2003-04X-03522-32A, K2006-04X-03522-35-3 and 72X-109
- Swedish Heart and Lung Foundation. Grant Number: 2004-0645 and 2006-0329
- Swedish Diabetes Association
- Ingabritt and Arne Lundberg Foundation
- Wallenberg Foundation
- islet arteriole;
- islet of Langerhans
Pancreatic islet blood flow is regulated separately from that of the exocrine pancreas, and a consistent finding during impaired glucose tolerance is an increased blood perfusion. The aim of the present study was to investigate whether C-peptide affects pancreatic islet arterioles in normal and diabetic mice.
Materials and Methods
Control and diabetic C57-Bl mice were studied after 2 weeks of alloxan-induced diabetes. Islet arterioles were dissected and microperfused with Dulbecco's modified Eagle medium (DMEM) solution. The effect of luminal application of mouse C-peptide was investigated.
C-peptide reduced the diameter of islet arterioles from diabetic mice (−10 ± 4%, P < 0.05) compared to base-line values, whilst arterioles from normoglycaemic animals did not respond to C-peptide (P = 0.2).
These findings suggest a role for C-peptide in the regulation of islet blood flow, especially during conditions with impaired glucose tolerance. Copyright © 2007 John Wiley & Sons, Ltd.