Research Article

The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy

  1. Sung Hoon Yu1,3,†,
  2. Sunmin Park2,†,
  3. Hun-Sung Kim1,
  4. So-Young Park1,
  5. Chang Hoon Yim1,
  6. Ki Ok Han1,
  7. Hyun Koo Yoon1,
  8. Hak Chul Jang3,
  9. Ho Yeon Chung4,
  10. Sung-Hoon Kim1,*

Article first published online: 29 APR 2009

DOI: 10.1002/dmrr.963

Issue

Diabetes/Metabolism Research and Reviews

Diabetes/Metabolism Research and Reviews

Volume 25, Issue 4, pages 329–334, May 2009

Additional Information

How to Cite

Yu, S. H., Park, S., Kim, H.-S., Park, S.-Y., Yim, C. H., Han, K. O., Yoon, H. K., Jang, H. C., Chung, H. Y. and Kim, S.-H. (2009), The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy. Diabetes/Metabolism Research and Reviews, 25: 329–334. doi: 10.1002/dmrr.963

Author Information

  1. 1

    Division of Endocrinology & Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea

  2. 2

    Department of Food & Nutrition, Hoseo University, Asan-Si, Korea

  3. 3

    Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea

  4. 4

    Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea

  1. †

    S.H.Y. and S. P. contributed equally to this work.

*Division of Endocrinology & Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea.

Publication History

  1. Issue published online: 29 APR 2009
  2. Article first published online: 29 APR 2009
  3. Manuscript Revised: 9 MAR 2009
  4. Manuscript Accepted: 9 MAR 2009
  5. Manuscript Received: 14 NOV 2008

Funded by

  • Korean Research Foundation in Korea. Grant Number: R04-2008-000-10078-0

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Keywords:

  • Gestational diabetes mellitus;
  • glutamic acid decarboxylase antibody;
  • Korean;
  • prevalence;
  • postpartum diabetes

Abstract

Background

We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth.

Methods

We studied 887 Korean women with GDM who were screened for GADA, and assessed their antepartum clinical characteristics and the outcomes of their pregnancies. At 6 weeks' postpartum, 75 g oral glucose tolerance tests were performed to determine the diabetic status of GDM women with GADA.

Results

The prevalence of GADA in Korean women with GDM was 1.7%. Plasma glucose levels at 0- and 3-h during oral glucose tolerance tests were significantly different between GADA-positive and GADA-negative women with GDM. There were no significant differences between them in terms of age, body mass index, family history of diabetes, fasting insulin, and lipid profiles. However, GADA-positive women with GDM required insulin treatment during pregnancy more frequently than GADA-negative patients. The development of diabetes at early postpartum was significantly higher in GADA-positive women with GDM than those who were GADA negative.

Conclusions

The prevalence of GADA in Korean women with GDM was low. However, GADA-positive women with GDM are more susceptible to subsequently developing type 1 diabetes, even in the early postpartum period. Long-term follow up studies and intervention to prevent type 1 diabetes among GADA-positive GDM women are needed. Copyright © 2009 John Wiley & Sons, Ltd.

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