Electric field effects on human spinal injury: Is there a basis in the in vitro studies?
Article first published online: 26 OCT 2007
Copyright © 2007 Wiley Periodicals, Inc.
Volume 68, Issue 2, pages 274–280, 1 February 2008
How to Cite
Robinson, K. R. and Cormie, P. (2008), Electric field effects on human spinal injury: Is there a basis in the in vitro studies?. Devel Neurobio, 68: 274–280. doi: 10.1002/dneu.20570
- Issue published online: 14 JAN 2008
- Article first published online: 26 OCT 2007
- Manuscript Accepted: 31 JUL 2007
- Manuscript Revised: 30 JUL 2007
- Manuscript Received: 25 JUN 2007
- NIH. Grant Number: R21 GM71768
- electric fields;
- spinal injury;
- neuronal galvanotropism
An important basis for the clinical application of small DC electric current to mammalian spinal injury is the responses of neurons in culture to applied electric fields. Our recent finding that zebrafish neurons were unresponsive to applied fields prompted us to critically examine previous results. We conclude that compelling evidence for neuronal guidance and directional stimulation of growth toward either the cathode or anode in an electric field exists only for cultured Xenopus neurons, and not for any mammalian neurons. No basis for the reported success in treating spinal injury exists in the in vitro studies, and considerable research will be required if the conditions of field application in mammalian spinal injury are to be optimized. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2008