Review Article

Emerging roles of neural stem cells in cerebral cortex development and evolution

  1. Víctor Borrell*,
  2. Isabel Reillo†

DOI: 10.1002/dneu.22013

Additional Information

Author Information

  1. Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas - Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain

  1. †

    Ph: 965919245; Fax: 965919561

*Instituto de Neurociencias, CSIC-UMH, Av. Ramón y Cajal s/n, 03550 Sant Joan d'Alacant, Spain

Publication History

  1. Accepted manuscript online: 10 FEB 2012 08:41AM EST
  2. Manuscript Revised: 6 FEB 2012
  3. Manuscript Accepted: 6 FEB 2012
  4. Manuscript Received: 2 DEC 2011

Funded by

  • International Human Frontier Science Program Organization. Grant Number: CDA0027/2007-C
  • Spanish Ministry of Science and Innovation. Grant Numbers: SAF2009-07367, CONSOLIDER CSD2007-00023

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Keywords:

  • OSVZ;
  • radial glia;
  • lissencephaly;
  • ferret;
  • neurogenesis

Abstract

Expansion and folding of the cerebral cortex are landmark features of mammalian brain evolution, which are recapitulated during embryonic development. Neural stem cells and their derived germinal cells are coordinated during cerebral cortex development to produce the appropriate amounts and types of neurons. This process is further complicated in gyrencephalic species, where newborn neurons must disperse in the tangential axis to expand the cerebral cortex in surface area. Here we review advances that have been made over the last decade in understanding the nature and diversity of telencephalic neural stem cells, and their roles in cortical development, and we discuss recent progress on how newly identified types of cortical progenitor cell populations may have evolved to drive the expansion and folding of the mammalian cerebral cortex. © 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012

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