Neural stem cells, adult neurogenesis, and galectin-1: From bench to bedside

Authors

  • Masanori Sakaguchi,

    1. Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Current affiliation:
    1. Lab for Memory Mechanisms, Brain Science Institute, RIKEN, Saitama, Japan
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  • Hideyuki Okano

    Corresponding author
    1. Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    • Department of Physiology, Keio University School of Medicine, Tokyo, Japan
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Abstract

Neural stem cells (NSCs) in the adult brain have been a consistent focus of biomedical research largely because of their potential clinical application. To fully exploit this potential, the molecular mechanisms that regulate NSCs must be clarified. Several lines of evidence show that a multifunctional protein, Galectin-1, is expressed and has a functional role in a subset of adult NSCs. Researchers, including our group, have explored the physiological role of Galectin-1 in NSCs and its application in the treatment of animal models of neurological disorders such as brain ischemia and spinal cord injury. Here, we summarize what is currently known regarding the role of Galectin-1 in adult NSCs. Furthermore, we discuss current issues in researching the role of Galectin-1 in adult NSCs under both physiological and pathological conditions. © 2012 Wiley Periodicals, Inc. Develop Neurobiol 72: 1059–1067, 2012

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