‘Smoking’ mephedrone: The identification of the pyrolysis products of 4-methylmethcathinone hydrochloride
Version of Record online: 28 MAY 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Drug Testing and Analysis
Volume 5, Issue 5, pages 291–305, May 2013
How to Cite
Kavanagh, P., O'Brien, J., Power, J. D., Talbot, B. and McDermott, S. D. (2013), ‘Smoking’ mephedrone: The identification of the pyrolysis products of 4-methylmethcathinone hydrochloride. Drug Test Analysis, 5: 291–305. doi: 10.1002/dta.1373
- Issue online: 24 MAY 2013
- Version of Record online: 28 MAY 2012
- Manuscript Accepted: 23 APR 2012
- Manuscript Revised: 22 APR 2012
- Manuscript Received: 27 FEB 2012
The ring-substituted cathinone – mephedrone – has gained popularity among recreational drug users over the past several years. It is generally consumed orally or by snorting but reports indicate that it is also ingested by vaporization/inhalation. This study examines the pyrolysis products produced by heating mephedrone under using simulated ‘meth pipe’ conditions. Thirteen pyrolysis products were identified, the major ones being iso-mephedrone, 4-methylpropiophenone, 4-methylphenylacetone, two pyrazine derivatives formed by dimerization of mephedrone, N-methylated mephedrone (N,N,4-trimethylcatinone), two hydroxylated oxidation products and a diketone. Other minor products formed were identified as 4-methylacetophenone, two α-chloro ketones and N-methylated iso-mephedrone. Copyright © 2012 John Wiley & Sons, Ltd.