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Screening of 30 acidic and neutral pharmaceuticals in whole blood by fully automated SPE and UPLC-TOF-MSE

Authors

  • Petur Weihe Dalsgaard,

    Corresponding author
    • Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark
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  • Andrej Jaroslav Rode,

    1. Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark
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  • Anders Just Pedersen,

    1. Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark
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  • Brian Schou Rasmussen,

    1. Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark
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  • Charlotte Norup Windberg,

    1. Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark
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  • Kristian Linnet

    1. Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark
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Correspondence to: Petur Weihe Dalsgaard, Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V's vej 11, 3. DK-2100, Denmark.

E-mail: petur.dalsgaard@forensic.ku.dk

Abstract

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A fully automated solid-phase extraction (SPE) and ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOF-MSE) method for screening of 30 acidic and neutral pharmaceuticals in whole blood was developed and validated.

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