A methamphetamine analog (N,α-diethyl-phenylethylamine) identified in a mainstream dietary supplement
Article first published online: 14 OCT 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Drug Testing and Analysis
Special Issue: New psychoactive substances part II
Volume 6, Issue 7-8, pages 805–807, July-August 2014
How to Cite
Cohen, P. A., Travis, J. C. and Venhuis, B. J. (2014), A methamphetamine analog (N,α-diethyl-phenylethylamine) identified in a mainstream dietary supplement. Drug Test Analysis, 6: 805–807. doi: 10.1002/dta.1578
- Issue published online: 17 JUL 2014
- Article first published online: 14 OCT 2013
- Manuscript Accepted: 1 OCT 2013
- Manuscript Revised: 10 SEP 2013
- Manuscript Received: 23 JUL 2013
- dietary supplements;
Pharmaceuticals and banned substances have been detected in hundreds of purportedly natural supplements. Recently, several athletes have been disqualified from competition after testing positive for the methamphetamine analog N,α-diethyl-phenylethylamine (N,α-DEPEA). Athletes have claimed they unknowingly consumed the banned stimulant in workout supplements. Three samples from different lot numbers of Craze, a workout supplement, were analyzed to detect the presence and concentration of N,α-DEPEA. Two labs independently identified N,α-DEPEA in the supplement using ultra high performance liquid chromatography (UHPLC) coupled to an LTQ Orbitrap XL mass spectrometer and UHPLC-quadruple-time-of-flight mass (Q-TOF) spectrometer, respectively. The identity of N,α-DEPEA was confirmed using nuclear magnetic resonance and reference standards. Manufacturer recommended servings were estimated to provide 21 to 35 mg of N,α-DEPEA. N,α-DEPEA has never been studied in humans. N,α-DEPEA is a methamphetamine analog; however, its stimulant, addictive and other adverse effects in humans are entirely unknown. Regulatory agencies should act expeditiously to warn consumers and remove N,α-DEPEA from all dietary supplements. Copyright © 2013 John Wiley & Sons, Ltd.