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Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes

  1. Elmorsy Khaled1,*,
  2. H. N. A. Hassan1,
  3. Gehad G. Mohamed2,
  4. Aly Eldin A. Seleim3

Article first published online: 13 SEP 2010

DOI: 10.1002/dta.159

Issue

Drug Testing and Analysis

Drug Testing and Analysis

Volume 2, Issue 9, pages 424–429, September 2010

Additional Information

How to Cite

Khaled, E., Hassan, H. N. A., Mohamed, G. G. and Seleim, A. E. A. (2010), Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes. Drug Test Analysis, 2: 424–429. doi: 10.1002/dta.159

Author Information

  1. 1

    Microanalysis Laboratory, National Research Centre, Dokki, Giza, 14211 Egypt

  2. 2

    Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt

  3. 3

    Critical Care Department, Faculty of Medicine, Cairo University, Giza, 12613 Egypt

*Microanalysis Laboratory, National Research Centre, Dokki, Giza, 14211 Egypt.

Publication History

  1. Issue published online: 16 SEP 2010
  2. Article first published online: 13 SEP 2010
  3. Manuscript Accepted: 20 JUN 2010
  4. Manuscript Revised: 10 JUN 2010
  5. Manuscript Received: 5 APR 2010

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Keywords:

  • disposable screen-printed carbon electrode;
  • potentiometry;
  • dextromethorphan;
  • flow injection analysis (FIA);
  • pharmaceutical preparations

Abstract

A simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen-printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10−5 to 10−2 mol L−1 with detection limit reaching 6 × 10−6 mol L−1 and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h−1. Copyright © 2010 John Wiley & Sons, Ltd.

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