Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes
Article first published online: 13 SEP 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Drug Testing and Analysis
Volume 2, Issue 9, pages 424–429, September 2010
How to Cite
Khaled, E., Hassan, H. N. A., Mohamed, G. G. and Seleim, A. E. A. (2010), Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes. Drug Test Analysis, 2: 424–429. doi: 10.1002/dta.159
- Issue published online: 16 SEP 2010
- Article first published online: 13 SEP 2010
- Manuscript Accepted: 20 JUN 2010
- Manuscript Revised: 10 JUN 2010
- Manuscript Received: 5 APR 2010
- disposable screen-printed carbon electrode;
- flow injection analysis (FIA);
- pharmaceutical preparations
A simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen-printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10−5 to 10−2 mol L−1 with detection limit reaching 6 × 10−6 mol L−1 and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h−1. Copyright © 2010 John Wiley & Sons, Ltd.