Mini Review

Khat a drug of abuse: roles of free radicals and antioxidants†

  1. Samir L. Aleryani1,*,
  2. Rowaida A. Aleryani‡,
  3. Ahmed A. Al-Akwa2

Article first published online: 2 DEC 2010

DOI: 10.1002/dta.224

Issue

Drug Testing and Analysis

Drug Testing and Analysis

Special Issue: Illicit Drugs

Volume 3, Issue 9, pages 548–551, September 2011

Additional Information

How to Cite

Aleryani, S. L., Aleryani, R. A. and Al-Akwa, A. A. (2011), Khat a drug of abuse: roles of free radicals and antioxidants. Drug Test Analysis, 3: 548–551. doi: 10.1002/dta.224

Author Information

  1. 1

    Vanderbilt University, The Vanderbilt Clinic, Nashville, TN 37232-5310, USA

  2. 2

    Department of Clinical Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana'a University, Yemen

  1. ‡

    Yemen Women Union, Sana'a, Yemen

*Vanderbilt University, The Vanderbilt Clinic, Nashville, TN 37232-5310, USA.

  1. †

    This article was published online on 2 December 2010. An error was subsequently identified in the author affiliations section of the manuscript. This notice is included in the online and print versions to indicate that both have been corrected on 5 March 2011.

Publication History

  1. Issue published online: 29 SEP 2011
  2. Article first published online: 2 DEC 2010
  3. Manuscript Revised: 10 OCT 2010
  4. Manuscript Accepted: 10 OCT 2010
  5. Manuscript Received: 15 SEP 2010

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Keywords:

  • Khat;
  • free radicals;
  • reactive oxygen species;
  • reactive nitrogen species;
  • cellular damage;
  • liver;
  • superoxide

Many articles have reviewed the health impact of Khat consumption; however the role of free radicals in the pathogenesis associated with short- and long-term consumption of Khat is absent in the literature. As free radicals and antioxidants converge across various mechanisms in normal physiological function and in disease, this review attempts to uncover the role of endogenous free radicals and the mechanism of cellular injury associated with Khat consumption. Copyright © 2010 John Wiley & Sons, Ltd.

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