Drug Testing and Analysis

Cover image for Vol. 3 Issue 6

June 2011

Volume 3, Issue 6

Pages 337–399

  1. Historical

    1. Top of page
    2. Historical
    3. Research articles
    4. Short communications
    1. Early drug discovery and the rise of pharmaceutical chemistry (pages 337–344)

      Professor Alan Wayne Jones

      Article first published online: 23 JUN 2011 | DOI: 10.1002/dta.301

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      The first medicinal drugs came from nature and were contained in various herbs, plants, roots, vines and fungi. Pharmaceutical companies were spin-offs from the synthetic dye industry and made use of the rich source of aromatic compounds contained in coal-tar. By the late 19th century the first synthetic drugs appeared, such as chloral hydrate (hypnotic), acetanilide, phenacetin, aspirin (antipyretics) and barbital (sleeping aid) all of which entered the pharmacopoeia.

  2. Research articles

    1. Top of page
    2. Historical
    3. Research articles
    4. Short communications
    1. Purification of pharmaceutical preparations using thin-layer chromatography to obtain mass spectra with Direct Analysis in Real Time and accurate mass spectrometry (pages 345–351)

      Jessica L. Wood and Robert R. Steiner

      Article first published online: 6 MAY 2011 | DOI: 10.1002/dta.293

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      A standard library of Direct Analysis in Real Time spectra were generated after purification of pharmaceutica preparations by TLC.

    2. Simultaneous estimation of atorvastatin and its two metabolites from human plasma by ESI-LC-MS/MS (pages 352–362)

      Chinmoy Ghosh, Ina Jain, Shashank Gaur, Niraj Patel, Anita Upadhyay and Bhaswat S. Chakraborty

      Article first published online: 9 FEB 2011 | DOI: 10.1002/dta.228

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      Atorvastatin and its two positional isomers o-hydroxy Atorvastatin and p-hydroxy Atorvastatin are simultaneously estimated from human plasma by ESI-LC-MS/MS. This is the most sensitive method with very short analysis time. Both the positional isomers are well resolved within this short analysis time.

    3. Characterization, thermal stability studies, and analytical method development of Paromomycin for formulation development (pages 363–372)

      Wahid Khan and Neeraj Kumar

      Article first published online: 29 DEC 2010 | DOI: 10.1002/dta.229

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      The present work describes characterization, thermal stability of Paromomycin on heat treatment and a sensitive HPLC analytical method as a pre-requirement for formulation development.

    4. PVC membrane sensor for potentiometric determination of iron (II) in some pharmaceutical formulations based on a new neutral ionophore (pages 373–379)

      M. A. Abounassif, M. A. Al-Omar, A.-G. E. Amr and G. A. E. Mostafa

      Article first published online: 29 DEC 2010 | DOI: 10.1002/dta.231

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      A Chiral 2,6-bis(carboxamide methyl ester)pyridine derivative has been prepared and examined as a novel natural carrier for ferrous ion in PVC matrix membrane sensor. The calibration curve was in the range of 1 × 10−3 to 6 × 10−6 M, with cationic slope of 31.5 ± 0.5 mV. The sensor is successfully applied.

    5. Rapid inexpensive assay method for verapamil by spectrophotometric sequential injection analysis (pages 380–386)

      Dr Abubakr M. Idris, Atta E. E. Ibrahim, Abdalla M. Abulkibash, Tawfik A. Saleh and Kamal E. E. Ibrahim

      Article first published online: 30 MAR 2011 | DOI: 10.1002/dta.277

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      An industrial-scale spectrophotometric sequential injection analysis (SIA) method for verapamil assay in pharmaceuticals was developed. Experimental design approaches were exploited for optimization in a short time with minimum effort and less consumption of reagents. Due to the miniaturization and automation of SIA, the method was rapid, safe for handling solutions, safe for the environment and inexpensiveness in terms of reagent consumption, instrumentation cost and manpower.

  3. Short communications

    1. Top of page
    2. Historical
    3. Research articles
    4. Short communications
    1. Spectral data analyses and structure elucidation of metoprolol tartrate (pages 387–392)

      Jun-qin Qiao, Ya-qin Wang, Chen-chen Liu, Wei Zhu, Hong-zhen Lian and Xin Ge

      Article first published online: 2 FEB 2011 | DOI: 10.1002/dta.257

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      The infrared spectrum, ultraviolet spectrum, mass spectrum, and nuclear magnetic resonance spectrum of metoprolol tartrate, an antiarrhythmic medicine, were reported and interpreted comprehensively.

    2. In vitro metabolic studies using homogenized horse liver in place of horse liver microsomes (pages 393–399)

      Dr Jenny K. Y. Wong, Francis P. W. Tang and Dr Terence S. M. Wan

      Article first published online: 5 MAR 2011 | DOI: 10.1002/dta.273

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      This paper describes the first report of the successful use of homogenized horse liver in place of horse liver microsomes for carrying out in vitro metabolism experiments.

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