Development of high performance liquid chromatography-ultraviolet detection method for screening mebendazole, clorsulon, diaveridine, and tolfenamic acid in animal-based food samples (pages 246–256)
Yun Pyo Kang, Jin Yu, Yoonyoung Huh, Jae Ho Oh, Chan Hyeok Kwon, Seul Ji Lee, Ji Won Ee, Geun Tae Kim, Jin Gyun Lee, Jeongmi Lee, Jeong Hill Park, You-Sun Kim and Sung Won Kwon
Article first published online: 10 APR 2013 | DOI: 10.1002/dta.1467
This paper focused on the method development for screening of residues of the four veterinary drugs, mebendazole, clorsulon, diaveridine, and tolfenamic acid in various food samples based on the maximum residue limit. With conditioning of liquid-liquid extraction and HPLC-UV analysis, the determinative methodology that consisted of common sample preparation step and instrumental analysis step was developed. Finally, the method was validated in accordance with the guidelines for Single-laboratory Validation of Analytical Methods for Trace-level Concentration of Organic Chemicals.