Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or ‘Serotoni’) (pages 684–695)
Simon D. Brandt, Michael H. Baumann, John S. Partilla, Pierce V. Kavanagh, John D. Power, Brian Talbot, Brendan Twamley, Olivia Mahony, John O'Brien, Simon P. Elliott, Roland P. Archer, Julian Patrick, Kuldip Singh, Nicola M. Dempster and Simon H. Cosbey
Article first published online: 19 MAY 2014 | DOI: 10.1002/dta.1668
4,4′-DMAR has recently been associated with 26 fatal intoxications in Europe. The present study describes the analytical characterization of both (±)-cis- and (±)-trans racemates, their synthesis, and the identification of the (±)-cis compound in a test purchase from an Internet vendor. Monoamine transporter activity studies in rat brain synaptosomes also showed that (±)-cis-4,4'-DMAR was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine, and serotonin.