Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression

Authors

  • Monica Bullejos,

    1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Current affiliation:
    1. Dpto. de Biología Experimental, Facultad de Ciencias Experimentales, Universidad de Jaén, Jaén E-23071, Spain
    Search for more papers by this author
  • Jo Bowles,

    1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Search for more papers by this author
  • Peter Koopman

    Corresponding author
    1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    • Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Search for more papers by this author

Abstract

Expression screening for genes preferentially expressed in mouse fetal ovaries relative to testes identified Cav-1 as a candidate female-specific gene. Cav-1 encodes caveolin-1, a component of the cell membrane invaginations known as caveolae, which are involved in lipid regulation and signal transduction. In situ hybridization revealed high levels of Cav-1 mRNA in developing ovaries, compared with moderate or low levels in testes. Analysis of caveolin-1 protein distribution by immunofluorescence showed this difference to be due to the development of a dense and complex vascular network in the developing ovary. These observations point to a higher degree of differentiation and organization of the early stage mammalian ovary than previously suspected. © 2002 Wiley-Liss, Inc.

Ancillary