Xath5 regulates neurogenesis in the Xenopus olfactory placode
Article first published online: 11 NOV 2002
Copyright © 2002 Wiley-Liss, Inc.
Special Issue: Xenopus Special Issue
Volume 225, Issue 4, pages 536–543, December 2002
How to Cite
Burns, C. J. and Vetter, M. L. (2002), Xath5 regulates neurogenesis in the Xenopus olfactory placode. Dev. Dyn., 225: 536–543. doi: 10.1002/dvdy.10189
- Issue published online: 25 NOV 2002
- Article first published online: 11 NOV 2002
- Manuscript Accepted: 23 SEP 2002
- Manuscript Received: 7 AUG 2002
- NIH. Grant Number: RO3 DC03530
- Pew Charitable Trusts
- olfactory neurogenesis;
Helix-loop-helix (HLH) genes function as important regulators of neurogenesis in both the peripheral and central nervous systems. The olfactory system is an ideal tissue in which to study the role of these genes in regulating the acquisition of neuronal cell fate, particularly that of the olfactory receptor neuron (ORN). Here we describe the expression of several basic HLH (bHLH) and repeat HLH (rHLH) factors during olfactory placode development in Xenopus laevis. Our work reveals that a combination of both bHLH and rHLH genes are sequentially expressed within the nascent olfactory placode during normal development. Moreover, overexpression of the bHLH factor, Xenopus atonal homologue 5 (Xath5), promotes olfactory neural fate independent of cellular proliferation within a restricted domain at the anterior of the embryo. Collectively, our data argue that HLH genes are expressed in a cascade during olfactory placode development and that the activity of an atonal homologue, Xath5, can promote ORN fate but only in the appropriate developmental context. © 2002 Wiley-Liss, Inc.