Tales of regeneration in zebrafish

Authors

  • Kenneth D. Poss,

    1. Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts
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  • Mark T. Keating,

    1. Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts
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  • Alex Nechiporuk

    Corresponding author
    1. Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts
    • Children's Hospital, 320 Longwood Avenue, Enders-1250.5, Boston, MA 02115
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Abstract

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. To address this deficiency, we and others have focused on the zebrafish model system. Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins. Developmental Dynamics 226:202–210, 2003. © 2003 Wiley-Liss, Inc.

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