Eye regeneration at the molecular age
Article first published online: 22 JAN 2003
Copyright © 2003 Wiley-Liss, Inc.
Special Issue: Regeneration Special Issue
Volume 226, Issue 2, pages 211–224, February 2003
How to Cite
Rio-Tsonis, K. D. and Tsonis, P. A. (2003), Eye regeneration at the molecular age. Dev. Dyn., 226: 211–224. doi: 10.1002/dvdy.10224
- Issue published online: 28 JAN 2003
- Article first published online: 22 JAN 2003
- Manuscript Accepted: 1 OCT 2002
- Manuscript Received: 26 AUG 2002
- NIH. Grant Numbers: EY 10540, EY 014197
- stem cells
Eye tissues such as the lens and the retina possess remarkable regenerative abilities. In amphibians, a complete lens can be regenerated after lentectomy. The process is a classic example of transdifferentiation of one cell type to another. Likewise, retina can be regenerated, but the strategy used to replace the damaged retina differs, depending on the animal system and the age of the animal. Retina can be regenerated by transdifferentiation or by the use of stem cells. In this review, we present a synthesis on the regenerative capacity of eye tissues in different animals with emphasis on the strategy and the molecules involved. In addition, we stress the place of this field at the molecular age and the importance of the recent technologic advances. Developmental Dynamics 226:211–224, 2003. © 2003 Wiley-Liss, Inc.